Our new paper related to the changes in dynamics of neuronal nuclei during aging was published!
- ykisi5
- Jul 24, 2023
- 1 min read
Our new paper has been published!
We have shown that the dynamics of the nucleus of a neuron decline with aging. In this study, we focused on the morphology of the nucleus during neuronal aging.
Previous reports have shown that the neuronal nucleus becomes infolded upon neuronal activity. However, there has been no report of real-time observation of the nuclei of neurons in vivo.
Therefore, we performed in vivo brain time-lapse imaging and found that the morphology of neuronal nuclei in young mice changes from a spherical shape to an infolded shape in about 10 minutes, depending on neuronal activity.
On the other hand, the nuclei of older mice, more than two years old, were infolded even before stimulation, and their morphology remained almost unchanged after neuronal activity. We also found that the nuclei became stiff.
Based on these results, we found a decrease in the dynamics of the nucleus as an important change associated with brain aging.
I find it interesting that skin also wrinkles and becomes stiffer during aging, and the same thing happens to the nuclei of neurons (although I do not think there is a direct relationship).
We were able to proceed this research with the great support of many collaborators: Dr. Murakami and Dr. Ohki at The University of Tokyo for time-lapse imaging of the living brain, Dr. Maki, Dr. Kawaue, Dr. Kengaku, Dr. Adachi at Kyoto University, and Dr. Nakazawa at Kindai University for the measurement of nuclear stiffness, and Dr. Tani and Dr. Ishiguro at Kumamoto University for the proteome analysis of nuclei. I thank them very much.
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